Relationship between asthma and cognition: The cooper center longitudinal study

G. Caldera-Alvarado, D. A. Khan, L. F. Defina, A. Pieper, E. S. Brown

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Background: Minimal data are available on the relationship between asthma and cognitive performance. In this report, we examine the relationship between asthma and cognitive performance in older adults, a subpopulation with elevated risk of cognitive impairment. Methods: We conducted a cross-sectional, retrospective analysis of 1380 participants age ≥55 who completed preventive health examinations at the Cooper Clinic in Dallas, TX. Cognition was assessed using the Montreal Cognitive Assessment (MoCA), a brief test for mild cognitive impairment. Data were analyzed in a multiple logistic regression using MoCA scores suggestive of cognitive impairment as the dependent variable. Results: When controlling for demographic characteristics, self-rated health status, inhaled corticosteroid use, and FEV1/FVC, asthma were associated with 78% increased risk of cognitive impairment (P = 0.02) as defined by MoCA score. Conclusions: In the largest sample examined to date, we have identified a significant relationship between asthma and cognitive impairment in older people.

Original languageEnglish (US)
Pages (from-to)545-548
Number of pages4
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number4
StatePublished - Apr 2013


  • asthma
  • cognition
  • corticosteroid
  • elderly
  • spirometry

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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