Regulation of the expression of adhesion molecules by human synoviocytes

Herbert B. Lindsley, Donald D. Smith, Laurie S. Davis, Alisa E. Koch, Peter E. Lipsky

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The capacity of synoviocytes to participate in inflammatory responses may be altered by the cytokine-enhanced expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). To examine this possibility, the ability of selected cytokines to enhance ICAM-1 expression was examined. The data indicated that each of these cytokines (interleukin-1β > tumor necrosis factor-α, interferon-γ ≫ interleukin-6) can up-regulate synoviocyte ICAM-1 expression. This can potentially increase the ability of these cells to interact with infiltrating inflammatory cells, thereby propagating immunologically mediated inflammation such as occurs in rheumatoid synovitis.

Original languageEnglish (US)
Pages (from-to)330-334
Number of pages5
JournalSeminars in Arthritis and Rheumatism
Issue number5
StatePublished - Apr 1992


  • ICAM-1
  • Synovial membrane
  • cell-adhesion molecules
  • cytokine
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Anesthesiology and Pain Medicine


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