TY - JOUR
T1 - Regulation of the enzymatic and motor activities of myosin I
AU - Barylko, Barbara
AU - Binns, Derk D.
AU - Albanesi, Joseph P.
PY - 2000/3/17
Y1 - 2000/3/17
N2 - Myosins I were the first unconventional myosins to be purified and they remain the best characterized. They have been implicated in various motile processes, including organelle translocation, ion channel gating and cytoskeletal reorganization but their exact cellular functions are still unclear. All members of the myosin I family, from yeast to man, have three structural domains: a catalytic head domain that binds ATP and actin; a tail domain believed to be involved in targeting the myosins to specific subcellular locations and a junction or neck domain that connects them and interacts with light chains. In this review we discuss how each of these three domains contributes to the regulation of myosin I enzymatic activity, motor activity and subcellular localization. (C) 2000 Elsevier Science B.V.
AB - Myosins I were the first unconventional myosins to be purified and they remain the best characterized. They have been implicated in various motile processes, including organelle translocation, ion channel gating and cytoskeletal reorganization but their exact cellular functions are still unclear. All members of the myosin I family, from yeast to man, have three structural domains: a catalytic head domain that binds ATP and actin; a tail domain believed to be involved in targeting the myosins to specific subcellular locations and a junction or neck domain that connects them and interacts with light chains. In this review we discuss how each of these three domains contributes to the regulation of myosin I enzymatic activity, motor activity and subcellular localization. (C) 2000 Elsevier Science B.V.
KW - Isoleucine-glutamine (IQ) domain
KW - Phosphorylation
KW - Unconventional myosin
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U2 - 10.1016/S0167-4889(00)00006-9
DO - 10.1016/S0167-4889(00)00006-9
M3 - Review article
C2 - 10722874
AN - SCOPUS:0034678115
SN - 0167-4889
VL - 1496
SP - 23
EP - 35
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 1
ER -