Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases

Yuntao S. Mao, Helen L. Yin

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations


Phosphatidylinositol (4,5)-bisphosphate (PIP2) is an important lipid mediator that has multiple regulatory functions. There is now increasing evidence that the phosphatidylinositol 4-phosphate 5 kinases (PIP5Ks), which synthesize PIP2, are regulated spatially and temporally and that they have isoform-specific functions and regulations. This review will summarize the highlights of recent developments in understanding how the three major PIP5K isoforms regulate the actin cytoskeleton and other important cellular processes.

Original languageEnglish (US)
Pages (from-to)5-18
Number of pages14
JournalPflugers Archiv European Journal of Physiology
Issue number1
StatePublished - Oct 2007


  • Actin cytoskeleton
  • Arf6
  • Endocytosis
  • PIP
  • PIP5K
  • Phagocytosis

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)


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