Abstract
Phosphatidylinositol (4,5)-bisphosphate (PIP2) is an important lipid mediator that has multiple regulatory functions. There is now increasing evidence that the phosphatidylinositol 4-phosphate 5 kinases (PIP5Ks), which synthesize PIP2, are regulated spatially and temporally and that they have isoform-specific functions and regulations. This review will summarize the highlights of recent developments in understanding how the three major PIP5K isoforms regulate the actin cytoskeleton and other important cellular processes.
Original language | English (US) |
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Pages (from-to) | 5-18 |
Number of pages | 14 |
Journal | Pflugers Archiv European Journal of Physiology |
Volume | 455 |
Issue number | 1 |
DOIs | |
State | Published - Oct 2007 |
Keywords
- Actin cytoskeleton
- Arf6
- Endocytosis
- PIP
- PIP5K
- Phagocytosis
ASJC Scopus subject areas
- Physiology
- Clinical Biochemistry
- Physiology (medical)