Abstract
Regulation of N-methyl-D-aspartate (NMDA) receptor activity by kinases and phosphatases contributes to the modulation of synaptic transmission. Targeting of these enzymes near the substrate is proposed to enhance phosphorylation-dependent modulation. Yotiao, an MMDA receptor-associated protein, bound the type 1 protein phosphatase (PP1) and the adenosine 3',5'- monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme. Anchored PP1 was active, limiting channel activity, whereas PKA activation overcame constitutive PP1 activity and conferred rapid enhancement of MMDA receptor currents. Hence, yotiao is a scaffold protein that physically attaches PP1 and PKA to NMDA receptors to regulate channel activity.
Original language | English (US) |
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Pages (from-to) | 93-96 |
Number of pages | 4 |
Journal | Science |
Volume | 285 |
Issue number | 5424 |
DOIs | |
State | Published - Jul 2 1999 |
ASJC Scopus subject areas
- General