Regulation of mtorc1 by upstream stimuli

Chase H. Melick, Jenna L. Jewell

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


The mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr protein kinase that senses multiple upstream stimuli to control cell growth, metabolism, and autophagy. mTOR is the catalytic subunit of mTOR complex 1 (mTORC1). A significant amount of research has uncovered the signaling pathways regulated by mTORC1, and the involvement of these signaling cascades in human diseases like cancer, diabetes, and ageing. Here, we review advances in mTORC1 regulation by upstream stimuli. We specifically focus on how growth factors, amino acids, G-protein coupled receptors (GPCRs), phosphorylation, and small GTPases regulate mTORC1 activity and signaling.

Original languageEnglish (US)
Article number989
Pages (from-to)1-28
Number of pages28
Issue number9
StatePublished - Sep 2020


  • Amino acids
  • And autophagy
  • Cell growth
  • G-protein coupled receptors
  • Kinases
  • MTORC1
  • Metabolism
  • Phosphorylation
  • Small GTPases

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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