Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells

Feng Li; Janice Ortega; Liya Gu; Guo Min Li

doi:10.1016/j.dnarep.2015.11.021

Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells

Feng Li, Janice Ortega, Liya Gu, Guo Min Li

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.

Original language	English (US)
Pages (from-to)	68-74
Number of pages	7
Journal	DNA repair
Volume	38
DOIs	https://doi.org/10.1016/j.dnarep.2015.11.021
State	Published - Feb 1 2016

Keywords

Deacetylase
H3K36me3
Histone methylation
MSH2
PCNA
Phosphorylation
Ubiquitination

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.dnarep.2015.11.021

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title = "Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells",

abstract = "DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.",

keywords = "Deacetylase, H3K36me3, Histone methylation, MSH2, PCNA, Phosphorylation, Ubiquitination",

author = "Feng Li and Janice Ortega and Liya Gu and Li, {Guo Min}",

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year = "2016",

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doi = "10.1016/j.dnarep.2015.11.021",

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TY - JOUR

T1 - Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells

AU - Li, Feng

AU - Ortega, Janice

AU - Gu, Liya

AU - Li, Guo Min

PY - 2016/2/1

Y1 - 2016/2/1

N2 - DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.

AB - DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.

KW - Deacetylase

KW - H3K36me3

KW - Histone methylation

KW - MSH2

KW - PCNA

KW - Phosphorylation

KW - Ubiquitination

UR - http://www.scopus.com/inward/record.url?scp=84956647649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956647649&partnerID=8YFLogxK

U2 - 10.1016/j.dnarep.2015.11.021

DO - 10.1016/j.dnarep.2015.11.021

M3 - Review article

C2 - 26719139

AN - SCOPUS:84956647649

SN - 1568-7864

VL - 38

SP - 68

EP - 74

JO - DNA repair

JF - DNA repair

ER -

Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells

Abstract

Keywords

ASJC Scopus subject areas

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