Abstract
DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 68-74 |
| Number of pages | 7 |
| Journal | DNA repair |
| Volume | 38 |
| DOIs | |
| State | Published - Feb 1 2016 |
Keywords
- Deacetylase
- H3K36me3
- Histone methylation
- MSH2
- PCNA
- Phosphorylation
- Ubiquitination
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology