Regulation of lung surfactant secretion by microRNA-150

Tingting Weng, Amarjit Mishra, Yujie Guo, Yang Wang, Lijing Su, Chaoqun Huang, Chunling Zhao, Xiao Xiao, Lin Liu

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


P2X7 receptor (P2X7R) is a purinergic ion-channel receptor. We have previously shown that the activation of P2X7R in alveolar type I cells stimulates surfactant secretion in alveolar type II cells. In this study, we determined whether miR-150 regulates P2X7R-mediated surfactant secretion. The miR-150 expression level in alveolar type II cells was much higher than alveolar type I cells, which was inversely correlated with the P2X7R protein level. An adenovirus expressing miR-150 significantly reduced the P2X7R protein expression in E10 cells, an alveolar type I cell line. Furthermore, pre-treatment of E10 cells with the adenovirus reduced the surfactant secretion induced by E10 cell conditioned medium. Our study demonstrates that miR-150 regulates surfactant secretion through P2X7R.

Original languageEnglish (US)
Pages (from-to)586-589
Number of pages4
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Jun 15 2012
Externally publishedYes


  • MiR-150
  • P2X7R
  • Surfactant secretion

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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