Regulation of ion channels by secreted Klotho

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations


Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands and choroid plexus of the brain. Klotho exists in two forms, a membrane form and a soluble secreted form. Recent studies show that the secreted Klotho possess sialidase activity and regulates several ion channels via the activity. Removal of terminal sialic acids from N-glycan chains of the epithelial Ca 2+ channel TRPV5 and the renal K + channel ROMK by secreted Klotho exposes the underlying disaccharide galactose-N- acetylglucosamine, a ligand for galectin-1. Binding to galectin-1 at the extracellular surface prevents internalization and leads to accumulation of the channels on the plasma membrane. Future studies will investigate whether secreted Klotho regulates cell-surface expression of other membrane glycoproteins via the same mechanism.

Original languageEnglish (US)
Title of host publicationEndocrine FGFs and Klothos
Number of pages7
StatePublished - Apr 19 2012

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Regulation of ion channels by secreted Klotho'. Together they form a unique fingerprint.

Cite this