Abstract
Transcription factor Foxo-1 can be inactivated via Akt-mediated phosphorylation. Since shear stress activates Akt, we determined whether Foxo-1 and the Foxo-1-dependent, angiogenesis-related Ang-2/Tie2-system are influenced by shear stress in endothelial cells. Expression of Foxo-1 and its target genes p27Kip1 and Ang-2 was decreased under shear stress (6 dyn/cm2, 24 h), nuclear exclusion of Foxo-1 by phosphorylation increased. eNOS and Tie2 were upregulated. No effects on Ang-1 expression were detected. In conclusion, Foxo-1 and Ang-2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis.
Original language | English (US) |
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Pages (from-to) | 673-680 |
Number of pages | 8 |
Journal | FEBS Letters |
Volume | 581 |
Issue number | 4 |
DOIs | |
State | Published - Feb 20 2007 |
Externally published | Yes |
Keywords
- Ang-2
- Angiogenesis
- Endothelium
- Foxo-1
- Shear stress
- Tie2
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology