Registration and fusion of SPECT, high-resolution MRI, and interventional MRI for thermal ablation of prostate cancer

Baowei Fei, Zhenghong Lee, Daniel T. Boll, Jeffery L. Duerk, D. Brace Sodee, Jonathan S. Lewin, David L. Wilson

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


We are investigating interventional MRI (iMRI) guided radiofrequency thermal ablation for the minimally invasive treatment of the prostate cancer. Nuclear medicine can detect and localize tumor in the prostate not reliably seen in MRI. We intend to combine the advantages of functional images such as nuclear medicine SPECT with iMRI-guided treatments. Our concept is to first register the low-resolution SPECT with a high-resolution MRI volume. Then by registering the high-resolution MR image with live-time iMRI acquisitions, we can, in turn, map the functional data and high-resolution anatomic information to live-time iMRI images for improved tumor targeting. For the first step, we used a three-dimensional mutual information registration method. For the latter, we developed a robust slice to volume (SV) registration algorithm with special features. The concept was tested using image data from three patients and three volunteers. The SV registration accuracy was 0.4 mm ± 0.2 mm as compared to our volume-to-volume registration that was previously shown to be quite accurate for these image pairs. With our image registration and fusion software, simulation experiments show that it is quite feasible to incorporate SPECT and high-resolution MRI into the iMRI-guided minimally invasive treatment procedures.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalIEEE Transactions on Nuclear Science
Issue number1 I
StatePublished - Feb 2004
Externally publishedYes


  • Fusion visualization
  • Image registration
  • Image-guided minimally invasive therapy
  • Interventional MRI
  • Prostate cancer

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering


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