Regioselective, Photocatalytic α-Functionalization of Amines

Lingying Leng; Yue Fu; Peng Liu; Joseph M. Ready

doi:10.1021/jacs.0c03758

Regioselective, Photocatalytic α-Functionalization of Amines

Lingying Leng, Yue Fu, Peng Liu, Joseph M. Ready

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Photocatalytic α-functionalization of amines provides a mild and atom-economical means to synthesize α-branched amines. Prior examples featured symmetrical or electronically biased substrates. Here we report a controllable α-functionalization of amines in which regioselectivity can be tuned with minor changes to the reaction conditions.

Original language	English (US)
Pages (from-to)	11972-11977
Number of pages	6
Journal	Journal of the American Chemical Society
Volume	142
Issue number	28
DOIs	https://doi.org/10.1021/jacs.0c03758
State	Published - Jul 15 2020

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/jacs.0c03758

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title = "Regioselective, Photocatalytic α-Functionalization of Amines",

abstract = "Photocatalytic α-functionalization of amines provides a mild and atom-economical means to synthesize α-branched amines. Prior examples featured symmetrical or electronically biased substrates. Here we report a controllable α-functionalization of amines in which regioselectivity can be tuned with minor changes to the reaction conditions.",

author = "Lingying Leng and Yue Fu and Peng Liu and Ready, {Joseph M.}",

note = "Funding Information: Funding from the Welch Foundation (I-1612), NIH (R01 CA216863), and NSF (CHE-1654122, P.L.). DFT calculations were performed at the Center for Research Computing at the University of Pittsburgh, and the Extreme Science and Engineering Discovery Environment supported by the National Science Foundation Grant No. ACI-1548562. Publisher Copyright: Copyright {\textcopyright} 2020 American Chemical Society.",

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AU - Fu, Yue

AU - Liu, Peng

AU - Ready, Joseph M.

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N2 - Photocatalytic α-functionalization of amines provides a mild and atom-economical means to synthesize α-branched amines. Prior examples featured symmetrical or electronically biased substrates. Here we report a controllable α-functionalization of amines in which regioselectivity can be tuned with minor changes to the reaction conditions.

AB - Photocatalytic α-functionalization of amines provides a mild and atom-economical means to synthesize α-branched amines. Prior examples featured symmetrical or electronically biased substrates. Here we report a controllable α-functionalization of amines in which regioselectivity can be tuned with minor changes to the reaction conditions.

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Regioselective, Photocatalytic α-Functionalization of Amines

Abstract

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