Regional tumor oxygenation and measurement of dynamic changes

Ralph P. Mason; Anca Constantinescu; Sandeep Hunjan; Dennis Le; Eric W. Hahn; Peter P. Antich; Christian Blum; Peter Peschke

doi:10.2307/3580323

Regional tumor oxygenation and measurement of dynamic changes

Ralph P. Mason, Anca Constantinescu, Sandeep Hunjan, Dennis Le, Eric W. Hahn, Peter P. Antich, Christian Blum, Peter Peschke

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

We recently described a novel approach to measuring regional tumor oxygen tension using ¹⁹F pulse burst saturation recovery (PBSR) nuclear magnetic resonance (NMR) echo planar imaging (EPI) relaxometry of hexafluorobenzene. We now compare oxygen tension measurements in a group of size-matched R3327-AT1 Dunning prostate rat tumors made using this new method with those using a traditional polarographic method: the Eppendorf histograph. Similar oxygen tension distributions were found using the two methods, and both techniques showed that tumors with volume greater than 3.5 cm³ were significantly (P < 0.0001) less well oxygenated than smaller tumors (volume less than 2 cm³). Using the ¹⁹F EPI approach, we also examined the response to respiratory challenge. Increasing the concentration of inspired oxygen from 33% to 100% O₂ produced a significant increase (P < 0.0001) in tumor oxygenation for a group of small tumors. In contrast, no change was observed in the mean pO₂ for a group of large tumors. Consideration of individual tumor regions irrespective of tumor size showed a strong correlation between the maximum pO₂ observed when breathing 100% O₂ compared with mean baseline pO₂. These results further demonstrate the usefulness of ¹⁹F EPI to assess changes in regional tumor oxygenation.

Original language	English (US)
Pages (from-to)	239-249
Number of pages	11
Journal	Radiation research
Volume	152
Issue number	3
DOIs	https://doi.org/10.2307/3580323
State	Published - Sep 1999

ASJC Scopus subject areas

Radiation
Biophysics
Radiology Nuclear Medicine and imaging

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title = "Regional tumor oxygenation and measurement of dynamic changes",

abstract = "We recently described a novel approach to measuring regional tumor oxygen tension using 19F pulse burst saturation recovery (PBSR) nuclear magnetic resonance (NMR) echo planar imaging (EPI) relaxometry of hexafluorobenzene. We now compare oxygen tension measurements in a group of size-matched R3327-AT1 Dunning prostate rat tumors made using this new method with those using a traditional polarographic method: the Eppendorf histograph. Similar oxygen tension distributions were found using the two methods, and both techniques showed that tumors with volume greater than 3.5 cm3 were significantly (P < 0.0001) less well oxygenated than smaller tumors (volume less than 2 cm3). Using the 19F EPI approach, we also examined the response to respiratory challenge. Increasing the concentration of inspired oxygen from 33% to 100% O2 produced a significant increase (P < 0.0001) in tumor oxygenation for a group of small tumors. In contrast, no change was observed in the mean pO2 for a group of large tumors. Consideration of individual tumor regions irrespective of tumor size showed a strong correlation between the maximum pO2 observed when breathing 100% O2 compared with mean baseline pO2. These results further demonstrate the usefulness of 19F EPI to assess changes in regional tumor oxygenation.",

author = "Mason, {Ralph P.} and Anca Constantinescu and Sandeep Hunjan and Dennis Le and Hahn, {Eric W.} and Antich, {Peter P.} and Christian Blum and Peter Peschke",

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AU - Constantinescu, Anca

AU - Hunjan, Sandeep

AU - Le, Dennis

AU - Hahn, Eric W.

AU - Antich, Peter P.

AU - Blum, Christian

AU - Peschke, Peter

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Regional tumor oxygenation and measurement of dynamic changes

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