Regional 133Xe washout data from normal and infarcted canine myocardia were collected using an Anger scintillation camera interfaced to a laboratory digital computer. Washout curves from selected regions were processed by a least squares estimation program to determine the parameters of a 3 compartment model. Various modifications in the methods of collection and generation of regional washout curves were evaluated by examining the change in the slope of the first component of the model. The results suggest that to maintain an expected error of 10% or less, single image data collection intervals of up to 10 sec and total data collection (observation) times down to 1.5 min can be used. In severely infarcted hearts where inhomogeneous flows exist, washout curves from areas at the infarct boundary larger than 1 cm2 tended to mask spatial flow patterns. An average error of 15.7% was detected when no compensation for nonmyocardial activity was performed on data from regions of infarction. Finally, the nonmyocardial background did not account for the tails (portion after 1.5 min) of washout curves from normal hearts.
|Number of pages
|Journal of Nuclear Medicine
|Published - Dec 1 1973
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging