Regional cerebral blood flow in female cocaine-addicted subjects following limbic activation

Bryon Adinoff, Michael D. Devous, Susan E. Best, Thomas S. Harris, Patricia Chandler, Sylva D. Frock, Mark J. Williams

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background: Cocaine dependence follows a different disease course in men and women, possibly as a consequence of sex-specific neurobiologic responses to chronic cocaine use. We have previously reported that male cocaine-dependent subjects demonstrate a significantly different limbic response to the limbic-stimulus procaine, as measured by regional cerebral blood flow (rCBF), compared with male controls. In this study, we assessed the limbic rCBF response to procaine in female cocaine-addicted subjects (n=10) and female controls (n=10). Methods: Subjects were administered 1.38 mg/kg procaine or saline intravenously in two separate sessions. Single photon emission computed tomography (SPECT) was used to compare the rCBF response to procaine. Results: Female cocaine-dependent subjects demonstrate a markedly muted, and distinctly different, limbic response to procaine compared with matched healthy controls. Conclusions: The rCBF response to procaine in female cocaine-dependent subjects suggests significant CNS differences compared with non-addicted female controls. Coupled with findings previously observed in male cocaine-dependent subjects, these biologic differences suggest that both male and female subjects experience alterations in limbic responsiveness following the chronic use of cocaine.

Original languageEnglish (US)
Pages (from-to)255-268
Number of pages14
JournalDrug and Alcohol Dependence
Issue number3
StatePublished - Sep 10 2003


  • Cocaine
  • Imaging
  • Limbic system
  • Procaine
  • Single-photon tomography
  • Women

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


Dive into the research topics of 'Regional cerebral blood flow in female cocaine-addicted subjects following limbic activation'. Together they form a unique fingerprint.

Cite this