TY - JOUR
T1 - Regeneration through Reprogramming Adult Cell Identity in Vivo
AU - Smith, Derek K.
AU - Zhang, Chun Li
N1 - Publisher Copyright:
© 2015 American Society for Investigative Pathology.
PY - 2015/10
Y1 - 2015/10
N2 - The discovery and in vivo application of cell fate reprogramming concepts have jumpstarted new technologies aimed at the functional regeneration of damaged tissues. As most adult organ systems retain only a limited potential for self-regeneration after trauma, the production of fate-specific cells by in vivo transdifferentiation offers a targeted method for tissue bioengineering. Proof-of-principle studies have demonstrated the induction of neural precursor cells, neurons, cardiomyocytes, and insulin-producing β islet cells. Each of these induced cell types survive, mature, and integrate into the local environment in a functionally meaningful manner. Here, we briefly highlight recent advances in the in vivo reprogramming of cell identity and the current challenges that face the clinical relevance of these methods.
AB - The discovery and in vivo application of cell fate reprogramming concepts have jumpstarted new technologies aimed at the functional regeneration of damaged tissues. As most adult organ systems retain only a limited potential for self-regeneration after trauma, the production of fate-specific cells by in vivo transdifferentiation offers a targeted method for tissue bioengineering. Proof-of-principle studies have demonstrated the induction of neural precursor cells, neurons, cardiomyocytes, and insulin-producing β islet cells. Each of these induced cell types survive, mature, and integrate into the local environment in a functionally meaningful manner. Here, we briefly highlight recent advances in the in vivo reprogramming of cell identity and the current challenges that face the clinical relevance of these methods.
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U2 - 10.1016/j.ajpath.2015.02.025
DO - 10.1016/j.ajpath.2015.02.025
M3 - Review article
C2 - 26056931
AN - SCOPUS:84943608359
SN - 0002-9440
VL - 185
SP - 2619
EP - 2628
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 10
M1 - 2053
ER -