Regeneration through Reprogramming Adult Cell Identity in Vivo

Derek K. Smith, Chun Li Zhang

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


The discovery and in vivo application of cell fate reprogramming concepts have jumpstarted new technologies aimed at the functional regeneration of damaged tissues. As most adult organ systems retain only a limited potential for self-regeneration after trauma, the production of fate-specific cells by in vivo transdifferentiation offers a targeted method for tissue bioengineering. Proof-of-principle studies have demonstrated the induction of neural precursor cells, neurons, cardiomyocytes, and insulin-producing β islet cells. Each of these induced cell types survive, mature, and integrate into the local environment in a functionally meaningful manner. Here, we briefly highlight recent advances in the in vivo reprogramming of cell identity and the current challenges that face the clinical relevance of these methods.

Original languageEnglish (US)
Article number2053
Pages (from-to)2619-2628
Number of pages10
JournalAmerican Journal of Pathology
Issue number10
StatePublished - Oct 2015

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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