Refractory Gastroesophageal Reflux Disease and Functional Heartburn

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


This report discusses the potential mechanisms that might underlie refractory GERD and functional heartburn, and how to distinguish among those mechanisms using a systematic evaluation that includes careful medical history, endoscopy with esophageal biopsy, esophageal manometry, and esophageal multichannel intraluminal impedance-pH monitoring. The report provides an approach to patient management that depends on the underlying mechanism identified by this systematic evaluation.

Original languageEnglish (US)
Pages (from-to)343-359
Number of pages17
JournalGastrointestinal Endoscopy Clinics of North America
Issue number2
StatePublished - Apr 2020
Externally publishedYes


  • Functional heartburn
  • Fundoplication
  • Gastroesophageal reflux disease
  • Magnetic sphincter augmentation
  • Proton pump inhibitor
  • Reflux hypersensitivity

ASJC Scopus subject areas

  • Gastroenterology


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