Refining the telomere-telomerase hypothesis of aging and cancer

Shawn E. Holt, Jerry W. Shay, Woodring E. Wright

Research output: Contribution to journalArticlepeer-review

169 Scopus citations


While there has been substantial experimental evidence in support of the telomere-telomerase hypothesis of aging and cancer, it has been suggested that the theory has been oversimplified to the exclusion of alternative mechanisms in the progression of cancer. This review strives to present an overview of some of the areas that have not been well explained and to indicate where multiple interpretations of the data are possible.

Original languageEnglish (US)
Pages (from-to)836-839
Number of pages4
JournalNature biotechnology
Issue number7
StatePublished - Jul 1996


  • Immortalization
  • Proliferation
  • Quiescence
  • Senescence
  • Stem cells

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Molecular Medicine
  • Biomedical Engineering


Dive into the research topics of 'Refining the telomere-telomerase hypothesis of aging and cancer'. Together they form a unique fingerprint.

Cite this