Refining the telomere-telomerase hypothesis of aging and cancer

Shawn E. Holt; Jerry W. Shay; Woodring E. Wright

doi:10.1038/nbt0796-836

Refining the telomere-telomerase hypothesis of aging and cancer

Shawn E. Holt, Jerry W. Shay, Woodring E. Wright

Research output: Contribution to journal › Article › peer-review

171 Scopus citations

Abstract

While there has been substantial experimental evidence in support of the telomere-telomerase hypothesis of aging and cancer, it has been suggested that the theory has been oversimplified to the exclusion of alternative mechanisms in the progression of cancer. This review strives to present an overview of some of the areas that have not been well explained and to indicate where multiple interpretations of the data are possible.

Original language	English (US)
Pages (from-to)	836-839
Number of pages	4
Journal	Nature biotechnology
Volume	14
Issue number	7
DOIs	https://doi.org/10.1038/nbt0796-836
State	Published - Jul 1996

Keywords

Immortalization
Proliferation
Quiescence
Senescence
Stem cells

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology
Molecular Medicine
Biomedical Engineering

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10.1038/nbt0796-836

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abstract = "While there has been substantial experimental evidence in support of the telomere-telomerase hypothesis of aging and cancer, it has been suggested that the theory has been oversimplified to the exclusion of alternative mechanisms in the progression of cancer. This review strives to present an overview of some of the areas that have not been well explained and to indicate where multiple interpretations of the data are possible.",

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AB - While there has been substantial experimental evidence in support of the telomere-telomerase hypothesis of aging and cancer, it has been suggested that the theory has been oversimplified to the exclusion of alternative mechanisms in the progression of cancer. This review strives to present an overview of some of the areas that have not been well explained and to indicate where multiple interpretations of the data are possible.

KW - Immortalization

KW - Proliferation

KW - Quiescence

KW - Senescence

KW - Stem cells

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Refining the telomere-telomerase hypothesis of aging and cancer

Abstract

Keywords

ASJC Scopus subject areas

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