TY - JOUR
T1 - Reduction of new coronary events and new atherothrombotic brain infarction in older persons with diabetes mellitus, prior myocardial infarction, and serum low-density lipoprotein cholesterol ≥125 mg/dl treated with statins
AU - Aronow, Wilbert S.
AU - Ahn, Chul
AU - Gutstein, Hal
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Background. We report the incidence of new coronary events and new atherothrombotic brain infarction (ABI) in older men and women with diabetes mellitus, prior myocardial infarction, and a serum low-density lipoprotein (LDL) cholesterol of ≥125 mg/dl treated with statins and with no lipid-lowering drug. Methods. The incidence of new coronary events and of new ABI was investigated in an observational prospective study of 529 diabetics, mean age 79 ± 9 years, with prior myocardial infarction and a serum LDL cholesterol of ≥125 mg/dl treated with statins (279 persons or 53%) and no lipid-lowering drug (250 persons or 47%). Follow-up was 29 ± 18 months. Results. At follow-up, the stepwise Cox regression model showed that after controlling for other risk factors, the use of statins was associated with a 37% significant independent reduction in the incidence of new coronary events and with a 47% significant independent reduction in the incidence of new ABI. Conclusions. Use of statins was associated with a 37% significant, independent reduction in new coronary events and a 47% significant, independent reduction in new ABI in older men and women with diabetes mellitus, prior myocardial infarction, and a serum LDL cholesterol of ≥125 mg/dl. Elderly diabetics with prior myocardial infarction and increased serum LDL cholesterol should especially be treated with statins.
AB - Background. We report the incidence of new coronary events and new atherothrombotic brain infarction (ABI) in older men and women with diabetes mellitus, prior myocardial infarction, and a serum low-density lipoprotein (LDL) cholesterol of ≥125 mg/dl treated with statins and with no lipid-lowering drug. Methods. The incidence of new coronary events and of new ABI was investigated in an observational prospective study of 529 diabetics, mean age 79 ± 9 years, with prior myocardial infarction and a serum LDL cholesterol of ≥125 mg/dl treated with statins (279 persons or 53%) and no lipid-lowering drug (250 persons or 47%). Follow-up was 29 ± 18 months. Results. At follow-up, the stepwise Cox regression model showed that after controlling for other risk factors, the use of statins was associated with a 37% significant independent reduction in the incidence of new coronary events and with a 47% significant independent reduction in the incidence of new ABI. Conclusions. Use of statins was associated with a 37% significant, independent reduction in new coronary events and a 47% significant, independent reduction in new ABI in older men and women with diabetes mellitus, prior myocardial infarction, and a serum LDL cholesterol of ≥125 mg/dl. Elderly diabetics with prior myocardial infarction and increased serum LDL cholesterol should especially be treated with statins.
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U2 - 10.1093/gerona/57.11.M747
DO - 10.1093/gerona/57.11.M747
M3 - Article
C2 - 12403804
AN - SCOPUS:0036845594
SN - 1079-5006
VL - 57
SP - M747-M750
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 11
ER -