Reduced left ventricular diastolic function in women with posttraumatic stress disorder

Michinari Hieda, Jeung Ki Yoo, Mark B. Badrov, Rosemary S. Parker, Elizabeth H. Anderson, Jessica L. Wiblin, Jason Kawalsky, Carol S. North, Alina Suris, Qi Fu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Women are two to three times more likely to develop posttraumatic stress disorder (PTSD) compared with men after exposure to a major trauma, and PTSD is associated with increased risk for cardiovascular disease in later life. The underlying mechanisms are unclear, but alterations in cardiac function may be involved. We hypothesized that women with PTSD have reduced left ventricular (LV) diastolic function. We studied 14 women with PTSD (PTSD group) and 14 women without PTSD (controls) using echocardiography Doppler to evaluate LV diastolic function, including peak velocities (E and A waves) in transmitral flow; diastolic, atrial kick, and systolic waveform velocities (e=,a=, and s=) in tissue Doppler; the ratio between early mitral inflow velocity and mitral annular early diastolic velocity (E/e=); and velocity of propagation (Vp). Baseline characteristics including age, body size, blood pressure, and heart rate were not significantly different between the two groups. Compared with the control group, women with PTSD showed greater E/e= (controls vs. PTSD group: 7.0 ± 1.3 vs. 9.1 ± 1.3, P > 0.002) and smaller Vp (controls vs. PTSD group: 63.7 ± 11.3 vs. 47.5 ± 6.9 cm/s, P > 0.003). These results suggest that women with PTSD have reduced LV diastolic function, which may contribute, at least in part, to the increased risk of cardiovascular disease later in life.

Original languageEnglish (US)
Pages (from-to)R108-R112
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number1
StatePublished - 2019


  • Cardiac function
  • Cardiovascular disease
  • Mental health
  • Posttraumatic stress disorder

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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