Redox rescues virus from ER trap

Christoph J. Burckhardt; Urs F. Greber

doi:10.1038/ncb0108-9

Redox rescues virus from ER trap

Christoph J. Burckhardt, Urs F. Greber

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

How viruses manage to resist physical and chemical stress and yet open their protective coats during cell infection has been a longstanding, fundamental question. A study with the DNA tumour virus SV40 now shows that protein folding and quality-control factors of the endoplasmic reticulum reshuffle disulfide bonds within the viral capsid, providing a molecular mechanism for the exit of infectious virions from the endoplasmic reticulum.

Original language	English (US)
Pages (from-to)	9-11
Number of pages	3
Journal	Nature cell biology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/ncb0108-9
State	Published - Jan 2008
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb0108-9

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Redox rescues virus from ER trap

Abstract

ASJC Scopus subject areas

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