Recovery from severe arsenic-induced peripheral neuropathy with 2,3-dimercapto-1-propanesulphonic acid

P. M. Wax, C. A. Thornton

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Case Report: A 33-year-old female with a 1.5-year history of multisystem illness was diagnosed with arsenic poisoning. Twenty-four-hour urine arsenic was 1030 μg/dL (normal 0-99) and root hair arsenic was 130 μg/g (normal 0-3). Despite treatment with succimer meso-2,3-dimercaptosuccinic acid, her neuropathy progressed to ventilator dependence and quadriplegia. Subsequent intravenous treatment with 2,3-dimercapto-1-propanesulfonic acid sodium salt was associated with arsenic diuresis, marked neuropathic improvement, and extubation. At 1-year follow-up, neuropathy was limited to mild distal lower extremity weakness and sensory loss. The use of 2,3-dimercapto-I-propanesulphonic acid in the treatment of severe arsenic neuropathy was associated with increased urinary elimination of arsenic and dramatic clinical recovery.

Original languageEnglish (US)
Pages (from-to)777-780
Number of pages4
JournalJournal of Toxicology - Clinical Toxicology
Issue number7
StatePublished - 2000

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis


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