Recommendation of colorectal cancer testing among primary care patients younger than 50 with elevated risk

Celette Sugg Skinner, Chul Ahn, Ethan A. Halm, Wendy Pechero Bishop, Katharine McCallister, Joanne M. Sanders, David Farrell, Noel Santini, Amit G. Singal

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


In the era of precision medicine, efforts are needed to identify and tailor screening recommendations among elevated-risk patients. Individuals younger than 50 years are an important target population, as they comprise 15% of colorectal (CRC) cases and often present with more advanced disease than their 50 + counterparts. In this large study, 2470 patients ages 25–49 used a tablet-based program that assessed risks, matched risks with screening guidelines, and generated tailored printed guideline-concordant recommendations for patients and their providers. The tablet-based program identified 121 (4.9%) patients with risk factors warranting screening before age 50. Likelihood of risk warranting screening was greater for ages 40–49 than < 40 years (OR: 2.38), females than males (OR: 1.82), and African Americans (OR: 1.69) and non-Hispanic Whites (OR: 2.89) compared to Hispanics. Most common risk factors were family history of polyps (23.1%), personal history of inflammatory bowel disease (19.8%), and combined family history of CRC + polyps (18.2%). Receipt of guideline-concordant screening within 6 months of identification was low, including only 5.3% of those who needed colonoscopy and 13.3% for whom colonoscopy or FIT was recommended. Although elevated-risk patients younger than 50 years can be readily identified, more than notification is necessary to facilitate screening participation.

Original languageEnglish (US)
Pages (from-to)20-23
Number of pages4
JournalPreventive Medicine
StatePublished - Sep 2017


  • Cancer screening
  • Decision support
  • Tailored interventions

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Recommendation of colorectal cancer testing among primary care patients younger than 50 with elevated risk'. Together they form a unique fingerprint.

Cite this