Recombination in the class III region of the mouse major histocompatibility complex

Masayasu Yoshino, Tomoko Sagai, Kirsten Fischer Lindahl, Yutaka Toyoda, Yasuaki Shirayoshi, Ken ichi Matsumoto, Kimihiko Sugaya, Toshimichi Ikemura, Kazuo Moriwaki, Topshihiko Shiroishi

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The sites of meiotic recombination in the class II region of the mouse major histocompatibility complex (MHC) are clustered at hotspots. To search for hotspots in the class III region, we mapped combiantional break-points of 79 Ab: H2-D recombinants with 11 DNA markers; these included Tnx, the gene for an extracellular matrix protein, tenascin X, the Notch-related Int3 gene, and a microsatellite marker, D17Mit13, none of which had previously been mapped precisely. The results gave the gene order Eb-61.11-Int3-Tnx-Cyp21/C4-Bf-Hsp68c-D17Mit13-Tnfa/Tnfb-D. The crossover sites in 40 of the 79 recombinants were cofiend within the Eb/Int3:Tnx/Cyp21 interval. The result demonstrated that an unequal distribution of recombination is a general feature of the mouse MHC, suggesting the presence of a recombinational hotsopt within the Int3:Tnx interval.

Original languageEnglish (US)
Pages (from-to)280-286
Number of pages7
Issue number4
StatePublished - Aug 1 1994

ASJC Scopus subject areas

  • Immunology
  • Genetics


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