Recognizing Inadequate Response in Patients With Major Depressive Disorder

W. Clay Jackson, George I. Papakostas, Roueen Rafeyan, Madhukar H. Trivedi

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


​​ ​​ Being able to recognize inadequate response to antidepressant treatment and distinguish it from treatment-resistant depression is key in order for clinicians to provide appropriate therapies. Although definitions vary, nonresponse is often defined as less than 25% improvement on a standardized rating scale, and partial response, as more than 25% but less than 50% improvement. Residual symptoms characteristic of inadequate response (less than 50% improvement) include low mood, anxiety, irritability, guilt, and somatic symptoms. Various factors that may contribute to inadequate response to an antidepressant include inadequate dose or duration, poor adherence, and misdiagnosis. ​.

Original languageEnglish (US)
JournalThe Journal of clinical psychiatry
Issue number3
StatePublished - May 5 2020

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Recognizing Inadequate Response in Patients With Major Depressive Disorder'. Together they form a unique fingerprint.

Cite this