TY - JOUR
T1 - Reciprocal changes in fructose-6-phosphate,2-kinase and fructose-2,6-bisphosphatase activity in response to glucagon and epinephrine
AU - Richards, Carolyn Sue
AU - Yokoyama, Motoko
AU - Furuya, Eisuke
AU - Uyeda, Kosaku
N1 - Funding Information:
work was supported
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1982/2/11
Y1 - 1982/2/11
N2 - The effect of hormones on the enzymes responsible for the synthesis (fructose-6-P,2-kinase) and degradation (fructose-2,6-Pase) of fructose-2,6-P2 was examined in isolated rat hepatocytes. Glucagon (10-11 M), epinephrine (10-5 M), or calcium (2.4 mM) and A23187 (10-5 M) administration to hepatocytes produced simultaneous activation of fructose-2,6-Pase and inactivation of fructose-6-P,2-kinase within 2 minutes. The effect of epinephrine on these two enzymes was dependent on the presence of Ca++. These results suggest that the level of fructose-2,6-P2 is controlled by recriprocal changes in fructose-2,6-Pase and fructose-6-P,2-kinase activities.
AB - The effect of hormones on the enzymes responsible for the synthesis (fructose-6-P,2-kinase) and degradation (fructose-2,6-Pase) of fructose-2,6-P2 was examined in isolated rat hepatocytes. Glucagon (10-11 M), epinephrine (10-5 M), or calcium (2.4 mM) and A23187 (10-5 M) administration to hepatocytes produced simultaneous activation of fructose-2,6-Pase and inactivation of fructose-6-P,2-kinase within 2 minutes. The effect of epinephrine on these two enzymes was dependent on the presence of Ca++. These results suggest that the level of fructose-2,6-P2 is controlled by recriprocal changes in fructose-2,6-Pase and fructose-6-P,2-kinase activities.
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U2 - 10.1016/0006-291X(82)91359-6
DO - 10.1016/0006-291X(82)91359-6
M3 - Article
C2 - 6280705
AN - SCOPUS:0020064727
SN - 0006-291X
VL - 104
SP - 1073
EP - 1079
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -