Recent Technical Developments in ASL: A Review of the State of the Art

Luis Hernandez-Garcia, Verónica Aramendía-Vidaurreta, Divya S. Bolar, Weiying Dai, Maria A. Fernández-Seara, Jia Guo, Ananth J. Madhuranthakam, Henk Mutsaerts, Jan Petr, Qin Qin, Jonas Schollenberger, Yuriko Suzuki, Manuel Taso, David L. Thomas, Matthias J.P. van Osch, Joseph Woods, Moss Y. Zhao, Lirong Yan, Ze Wang, Li ZhaoThomas W. Okell

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


This review article provides an overview of a range of recent technical developments in advanced arterial spin labeling (ASL) methods that have been developed or adopted by the community since the publication of a previous ASL consensus paper by Alsop et al. It is part of a series of review/recommendation papers from the International Society for Magnetic Resonance in Medicine Perfusion Study Group. Here, we focus on advancements in readouts and trajectories, image reconstruction, noise reduction, partial volume correction, quantification of nonperfusion parameters, fMRI, fingerprinting, vessel selective ASL, angiography, deep learning, and ultrahigh field ASL. We aim to provide a high level of understanding of these new approaches and some guidance for their implementation, with the goal of facilitating the adoption of such advances by research groups and by MRI vendors. Topics outside the scope of this article that are reviewed at length in separate articles include velocity selective ASL, multiple-timepoint ASL, body ASL, and clinical ASL recommendations.

Original languageEnglish (US)
Pages (from-to)2021-2042
Number of pages22
JournalMagnetic resonance in medicine
Issue number5
StatePublished - Nov 2022
Externally publishedYes


  • CBF
  • MR imaging
  • arterial spin labeling
  • perfusion
  • technical advances
  • vascular imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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