TY - JOUR
T1 - Recent insights into mammalian ER–PM junctions
AU - Chen, Yu Ju
AU - Quintanilla, Carlo Giovanni
AU - Liou, Jen
N1 - Funding Information:
We thank the Liou Laboratory members for valuable discussions. This work was supported by National Institutes of Health grant GM113079 , Welch Foundation Grant I-1789 , and National Institutes of Health Cell and Molecular Biology Training Program T32 GM008203 . J. Liou is a Sowell Family Scholar in Medical Research.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/4
Y1 - 2019/4
N2 - ER–PM junctions are subcellular sites where the endoplasmic reticulum (ER) and the plasma membrane (PM) are kept in close appositions, providing a platform for inter-organelle contact. These membrane contact sites are important for many physiological functions in mammalian cells, including excitation–contraction coupling, store-operated Ca 2+ entry, and non-vesicular transfer of lipids between the ER and the PM. Here we review recent insights into the 3D structure and spatial organization of ER–PM junctions in mammalian cells as well as molecular mechanisms underlying the formation and functions of mammalian ER–PM junctions.
AB - ER–PM junctions are subcellular sites where the endoplasmic reticulum (ER) and the plasma membrane (PM) are kept in close appositions, providing a platform for inter-organelle contact. These membrane contact sites are important for many physiological functions in mammalian cells, including excitation–contraction coupling, store-operated Ca 2+ entry, and non-vesicular transfer of lipids between the ER and the PM. Here we review recent insights into the 3D structure and spatial organization of ER–PM junctions in mammalian cells as well as molecular mechanisms underlying the formation and functions of mammalian ER–PM junctions.
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U2 - 10.1016/j.ceb.2018.12.011
DO - 10.1016/j.ceb.2018.12.011
M3 - Review article
C2 - 30739879
AN - SCOPUS:85061194746
SN - 0955-0674
VL - 57
SP - 99
EP - 105
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -