Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis

Reshu Saini, Kenneth Hoyt

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


Angiogenesis is a critical process for tumor growth and metastatic dissemination. There is tremendous interest in the development of noninvasive methods for imaging tumor angiogenesis, and ultrasound (US) is an emerging platform technology to address this challenge. The introduction of intravascular microbubble contrast agents not only allows real-time visualization of tumor perfusion during an US examination, but they can be functionalized with specific ligands to permit molecular US imaging of angiogenic biomarkers that are overexpressed on the tumor endothelium. In this article, we will review current concepts and developing trends for US imaging of tumor angiogenesis, including relevant preclinical and clinical findings.

Original languageEnglish (US)
Pages (from-to)41-52
Number of pages12
JournalImaging in Medicine
Issue number1
StatePublished - Feb 2014


  • angiogenesis
  • contrast agent
  • microbubble
  • molecular imaging
  • ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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