@article{8604c38677bd425fa47e717641e22de5,
title = "Recent advances in understanding IP3R function with focus on ER-mitochondrial Ca2+ transfers",
abstract = "IP3 receptors (IP3Rs) are intracellular Ca2+ release channels gated by IP3 that are located in the endoplasmic reticulum (ER), including subregions that are in close contact with other organelles such as mitochondria. Recent studies have discovered unique properties of these channels in terms of the stoichiometric requirements for channel opening, their licensing to open in response to IP3 and their contribution to ER-mitochondrial contacts and Ca2+ transfers. In this mini-review, we provide a snapshot of the recent developments in our understanding of how IP3Rs impact and function at the ER-mitochondrial interface. We have focused this review on more recent discoveries that address questions such as: Which IP3R isoform is fueling Ca2+ to mitochondria? How are IP3Rs tethered to MAMs and how do IP3Rs contribute to MAM formation? And how are IP3Rs modulated at MAMs?",
author = "Jens Loncke and Martijn Kerkhofs and Allen Kaasik and Ilya Bezprozvanny and Geert Bultynck",
note = "Funding Information: Research in the authors{\textquoteright} laboratories was supported by research grants of the Research Foundation - Flanders ( FWO ) (grants G.0634.13N , G.0C91.14N , G.0A34.16N and G090118N to GB and grant G0E7520N to GB and IB), the Research Council - KU Leuven ( OT14/101 , C14/19/101 and AKUL/19/34 to GB), Central European Leuven Strategic Alliance ( CELSA/18/040 to GB and AK), Stichting Alzheimer Onderzoek (SAO IP3 RECEPTOR to GB), Eye Hope Foundation/Koning Boudewijnstichting ( 2020-J1160630-214966 to GB) and Russian Science Foundation (Grant 20-45-01004 to IB). MK obtained a doctoral fellowship from the FWO. Funding Information: Research in the authors? laboratories was supported by research grants of the Research Foundation - Flanders (FWO) (grants G.0634.13N, G.0C91.14N, G.0A34.16N and G090118N to GB and grant G0E7520N to GB and IB), the Research Council - KU Leuven (OT14/101, C14/19/101 and AKUL/19/34 to GB), Central European Leuven Strategic Alliance (CELSA/18/040 to GB and AK), Stichting Alzheimer Onderzoek (SAO IP3 RECEPTOR to GB), Eye Hope Foundation/Koning Boudewijnstichting (2020-J1160630-214966 to GB) and Russian Science Foundation (Grant 20-45-01004 to IB). MK obtained a doctoral fellowship from the FWO. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2020",
month = oct,
doi = "10.1016/j.cophys.2020.07.011",
language = "English (US)",
volume = "17",
pages = "80--88",
journal = "Current Opinion in Physiology",
issn = "2468-8681",
publisher = "Elsevier Ltd",
}