TY - JOUR
T1 - Recent advances in stem cell-based blastocyst models
AU - Oura, Seiya
AU - Hamilton, James N.
AU - Wu, Jun
N1 - Funding Information:
J.W. is a New York Stem Cell Foundation–Robertson Investigator and Virginia Murchison Linthicum Scholar in Medical Research and funded by the New York Stem Cell Foundation ( NYSCF ), US; the National Institutes of Health (NIH) ( HD103627–01A1NIH , GM138565–01A1 , and OD028763 ), US; and Welch ( 854671 ), US. S.O. is supported by the Naito Foundation , Japan.
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/8
Y1 - 2023/8
N2 - Early embryo development is a highly dynamic process that plays a crucial role in determining the health and characteristics of an organism. For many years, embryonic and extraembryonic stem cell lines representing various developmental stages have served as valuable models for studying early embryogenesis. As our understanding of stem cell culture and embryo development has advanced, researchers have been able to create more sophisticated 3D structures mimicking early embryos, such as blastocyst-like structures (blastoids). These innovative models represent a significant leap forward in the field. In this mini-review, we will discuss the latest progress in stem cell-based embryo models, explore potential future directions, and examine how these models contribute to a deeper understanding of early mammalian development.
AB - Early embryo development is a highly dynamic process that plays a crucial role in determining the health and characteristics of an organism. For many years, embryonic and extraembryonic stem cell lines representing various developmental stages have served as valuable models for studying early embryogenesis. As our understanding of stem cell culture and embryo development has advanced, researchers have been able to create more sophisticated 3D structures mimicking early embryos, such as blastocyst-like structures (blastoids). These innovative models represent a significant leap forward in the field. In this mini-review, we will discuss the latest progress in stem cell-based embryo models, explore potential future directions, and examine how these models contribute to a deeper understanding of early mammalian development.
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U2 - 10.1016/j.gde.2023.102088
DO - 10.1016/j.gde.2023.102088
M3 - Review article
C2 - 37451164
AN - SCOPUS:85164589609
SN - 0959-437X
VL - 81
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
M1 - 102088
ER -