Recent advances in antiviral interferon-stimulated gene biology

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


The interferon response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs), some of which encode effectors with varied antiviral functions. As screening technologies improve and mouse model development quickens, more ISGs are continually being identified, characterized mechanistically, and evaluated for protective roles in vivo. This review highlights selected recent findings of ISG effectors that contribute to our understanding of the interferon antiviral response.

Original languageEnglish (US)
Article number309
StatePublished - 2018


  • Antiviral interferon-stimulated genes
  • Interferon response
  • Viral pathogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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