Readers of histone modifications

Miyong Yun; Jun Wu; Jerry L. Workman; Bing Li

doi:10.1038/cr.2011.42

Readers of histone modifications

Miyong Yun, Jun Wu, Jerry L. Workman, Bing Li

Research output: Contribution to journal › Review article › peer-review

437 Scopus citations

Abstract

Histone modifications not only play important roles in regulating chromatin structure and nuclear processes but also can be passed to daughter cells as epigenetic marks. Accumulating evidence suggests that the key function of histone modifications is to signal for recruitment or activity of downstream effectors. Here, we discuss the latest discovery of histone-modification readers and how the modification language is interpreted.

Original language	English (US)
Pages (from-to)	564-578
Number of pages	15
Journal	Cell Research
Volume	21
Issue number	4
DOIs	https://doi.org/10.1038/cr.2011.42
State	Published - Apr 2011

Keywords

chromatin
epigenetics
histone modification

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/cr.2011.42

Cite this

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title = "Readers of histone modifications",

abstract = "Histone modifications not only play important roles in regulating chromatin structure and nuclear processes but also can be passed to daughter cells as epigenetic marks. Accumulating evidence suggests that the key function of histone modifications is to signal for recruitment or activity of downstream effectors. Here, we discuss the latest discovery of histone-modification readers and how the modification language is interpreted.",

keywords = "chromatin, epigenetics, histone modification",

author = "Miyong Yun and Jun Wu and Workman, {Jerry L.} and Bing Li",

year = "2011",

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AU - Yun, Miyong

AU - Wu, Jun

AU - Workman, Jerry L.

AU - Li, Bing

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N2 - Histone modifications not only play important roles in regulating chromatin structure and nuclear processes but also can be passed to daughter cells as epigenetic marks. Accumulating evidence suggests that the key function of histone modifications is to signal for recruitment or activity of downstream effectors. Here, we discuss the latest discovery of histone-modification readers and how the modification language is interpreted.

AB - Histone modifications not only play important roles in regulating chromatin structure and nuclear processes but also can be passed to daughter cells as epigenetic marks. Accumulating evidence suggests that the key function of histone modifications is to signal for recruitment or activity of downstream effectors. Here, we discuss the latest discovery of histone-modification readers and how the modification language is interpreted.

KW - chromatin

KW - epigenetics

KW - histone modification

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DO - 10.1038/cr.2011.42

M3 - Review article

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JF - Cell Research

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Readers of histone modifications

Abstract

Keywords

ASJC Scopus subject areas

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