Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis

Sanghee Yun, Ryan P. Reynolds, Irene Masiulis, Amelia J. Eisch

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations


People diagnosed with neuropsychiatric disorders such as depression, anxiety, addiction or schizophrenia often have dysregulated memory, mood, pattern separation and/or reward processing. These symptoms are indicative of a disrupted function of the dentate gyrus (DG) subregion of the brain, and they improve with treatment and remission. The dysfunction of the DG is accompanied by structural maladaptations, including dysregulation of adult-generated neurons. An increasing number of studies using modern inducible approaches to manipulate new neurons show that the behavioral symptoms in animal models of neuropsychiatric disorders can be produced or exacerbated by the inhibition of DG neurogenesis. Thus, here we posit that the connection between neuropsychiatric disorders and dysregulated DG neurogenesis is beyond correlation or epiphenomenon, and that the regulation of adult-generated DG neurogenesis merits continued and focused attention in the ongoing effort to develop novel treatments for neuropsychiatric disorders.

Original languageEnglish (US)
Pages (from-to)1239-1247
Number of pages9
JournalNature medicine
Issue number11
StatePublished - Nov 1 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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