TY - JOUR
T1 - (Re) Building a kidney
AU - Oxburgh, Leif
AU - Carroll, Thomas J.
AU - Cleaver, Ondine
AU - Gossett, Daniel R.
AU - Hoshizaki, Deborah K.
AU - Hubbell, Jeffrey A.
AU - Humphreys, Benjamin D.
AU - Jain, Sanjay
AU - Jensen, Jan
AU - Kaplan, David L.
AU - Kesselman, Carl
AU - Ketchum, Christian J.
AU - Little, Melissa H.
AU - McMahon, Andrew P.
AU - Shankland, Stuart J.
AU - Spence, Jason R.
AU - Valerius, M. Todd
AU - Wertheim, Jason A.
AU - Wessely, Oliver
AU - Zheng, Ying
AU - Drummond, Iain A.
N1 - Publisher Copyright:
© 2017 by the American Society of Nephrology.
PY - 2017/5
Y1 - 2017/5
N2 - (Re)Building a Kidney is aNational InstituteofDiabetes andDigestive andKidney Diseasesled consortium to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types andthe integrationof these cells into complexstructures that replicate human kidney function. The ultimate goals of the consortium are two-fold: To develop and implement strategies for in vitro engineering of replacement kidney tissue, and to devise strategies to stimulate regeneration of nephrons in situ to restore failing kidney function. Projectswithin the consortium will answer fundamental questions regardinghumangeneexpression in thedeveloping kidney, essential signaling crosstalkbetween distinct cell typesof the developing kidney,howtoderive the manycell typesof the kidney through directed differentiation of human pluripotent stem cells,which bioengineering or scaffolding strategies have the most potential for kidney tissue formation, and basic parameters of the regenerative response to injury. As these projects progress, the consortiumwill incorporate systematic investigations in physiologic function of in vitro and in vivo differentiated kidney tissue, strategies for engraftment in experimental animals, and development of therapeutic approaches to activate innate reparative responses.
AB - (Re)Building a Kidney is aNational InstituteofDiabetes andDigestive andKidney Diseasesled consortium to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types andthe integrationof these cells into complexstructures that replicate human kidney function. The ultimate goals of the consortium are two-fold: To develop and implement strategies for in vitro engineering of replacement kidney tissue, and to devise strategies to stimulate regeneration of nephrons in situ to restore failing kidney function. Projectswithin the consortium will answer fundamental questions regardinghumangeneexpression in thedeveloping kidney, essential signaling crosstalkbetween distinct cell typesof the developing kidney,howtoderive the manycell typesof the kidney through directed differentiation of human pluripotent stem cells,which bioengineering or scaffolding strategies have the most potential for kidney tissue formation, and basic parameters of the regenerative response to injury. As these projects progress, the consortiumwill incorporate systematic investigations in physiologic function of in vitro and in vivo differentiated kidney tissue, strategies for engraftment in experimental animals, and development of therapeutic approaches to activate innate reparative responses.
UR - http://www.scopus.com/inward/record.url?scp=85021850376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021850376&partnerID=8YFLogxK
U2 - 10.1681/ASN.2016101077
DO - 10.1681/ASN.2016101077
M3 - Article
C2 - 28096308
AN - SCOPUS:85021850376
SN - 1046-6673
VL - 28
SP - 1370
EP - 1378
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 5
ER -