Rational HCC screening approaches for patients with NAFLD

Amit G. Singal, Hashem B. El-Serag

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of developing hepatocellular carcinoma (HCC), especially among those who have cirrhosis or advanced fibrosis, but 20–30% of cases of NAFLD-related HCC occur in the absence of advanced fibrosis. The prevalence of NAFLD-related HCC is increasing in most countries worldwide. There are few direct data to support or refute the efficacy or effectiveness of HCC surveillance in NAFLD or to guide its application. We use evidence on surveillance in other conditions and studies on the clinical course of patients with NAFLD to arrive at recommendations for rational approaches to HCC surveillance in this growing cohort of patients. We also outline gaps in research and practice, including opportunities to advance the field.

Original languageEnglish (US)
Pages (from-to)195-201
Number of pages7
JournalJournal of Hepatology
Issue number1
StatePublished - Jan 2022


  • biomarkers
  • cirrhosis
  • fatty liver
  • guidelines
  • liver cancer
  • metabolic dysfunction
  • surveillance

ASJC Scopus subject areas

  • Hepatology


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