Rational design of amyloid binding agents based on the molecular rotor motif

Jeyanthy Sutharsan; Marianna Dakanali; Christina C. Capule; Mark A. Haidekker; Jerry Yang; Emmanuel A. Theodorakis

doi:10.1002/cmdc.200900440

Rational design of amyloid binding agents based on the molecular rotor motif

Jeyanthy Sutharsan, Marianna Dakanali, Christina C. Capule, Mark A. Haidekker, Jerry Yang, Emmanuel A. Theodorakis

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

New fluorescent probes, designed based on the molecular rotor motif, displayed good affinity for aggregated b-amyloid peptides. The physical and fluorescence properties of these probes can be fine tuned by modifying their chemical structures. These findings suggest that the general motif of molecular rotors can lead to the design of new diagnostic tools for amyloid imaging in Alzheimer's disease and related neurodegenerative conditions. (Chemical Equation Presented).

Original language	English (US)
Pages (from-to)	56-60
Number of pages	5
Journal	ChemMedChem
Volume	5
Issue number	1
DOIs	https://doi.org/10.1002/cmdc.200900440
State	Published - Jan 4 2010

Keywords

Amyloid peptides
Fluorescent probes
Imaging agents
Molecular rotors

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

Access to Document

10.1002/cmdc.200900440

Cite this

@article{9a5772a080934db7bb739de98bc76897,

title = "Rational design of amyloid binding agents based on the molecular rotor motif",

abstract = "New fluorescent probes, designed based on the molecular rotor motif, displayed good affinity for aggregated b-amyloid peptides. The physical and fluorescence properties of these probes can be fine tuned by modifying their chemical structures. These findings suggest that the general motif of molecular rotors can lead to the design of new diagnostic tools for amyloid imaging in Alzheimer's disease and related neurodegenerative conditions. (Chemical Equation Presented).",

keywords = "Amyloid peptides, Fluorescent probes, Imaging agents, Molecular rotors",

author = "Jeyanthy Sutharsan and Marianna Dakanali and Capule, {Christina C.} and Haidekker, {Mark A.} and Jerry Yang and Theodorakis, {Emmanuel A.}",

year = "2010",

month = jan,

day = "4",

doi = "10.1002/cmdc.200900440",

language = "English (US)",

volume = "5",

pages = "56--60",

journal = "ChemMedChem",

issn = "1860-7179",

publisher = "John Wiley and Sons Ltd",

number = "1",

}

TY - JOUR

T1 - Rational design of amyloid binding agents based on the molecular rotor motif

AU - Sutharsan, Jeyanthy

AU - Dakanali, Marianna

AU - Capule, Christina C.

AU - Haidekker, Mark A.

AU - Yang, Jerry

AU - Theodorakis, Emmanuel A.

PY - 2010/1/4

Y1 - 2010/1/4

N2 - New fluorescent probes, designed based on the molecular rotor motif, displayed good affinity for aggregated b-amyloid peptides. The physical and fluorescence properties of these probes can be fine tuned by modifying their chemical structures. These findings suggest that the general motif of molecular rotors can lead to the design of new diagnostic tools for amyloid imaging in Alzheimer's disease and related neurodegenerative conditions. (Chemical Equation Presented).

AB - New fluorescent probes, designed based on the molecular rotor motif, displayed good affinity for aggregated b-amyloid peptides. The physical and fluorescence properties of these probes can be fine tuned by modifying their chemical structures. These findings suggest that the general motif of molecular rotors can lead to the design of new diagnostic tools for amyloid imaging in Alzheimer's disease and related neurodegenerative conditions. (Chemical Equation Presented).

KW - Amyloid peptides

KW - Fluorescent probes

KW - Imaging agents

KW - Molecular rotors

UR - http://www.scopus.com/inward/record.url?scp=74849096430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74849096430&partnerID=8YFLogxK

U2 - 10.1002/cmdc.200900440

DO - 10.1002/cmdc.200900440

M3 - Article

C2 - 20024978

AN - SCOPUS:74849096430

SN - 1860-7179

VL - 5

SP - 56

EP - 60

JO - ChemMedChem

JF - ChemMedChem

IS - 1

ER -

Rational design of amyloid binding agents based on the molecular rotor motif

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this