TY - JOUR
T1 - Rate of progression from mild cognitive impairment to dementia in an essential tremor cohort
T2 - A prospective, longitudinal study
AU - Radler, Keith H.
AU - Zdrodowska, Maria Anna
AU - Dowd, Hollie
AU - Cersonsky, Tess E.K.
AU - Huey, Edward D.
AU - Cosentino, Stephanie
AU - Louis, Elan D.
N1 - Funding Information:
Funding by the National Institutes of Health R01NS086736
Publisher Copyright:
© 2020
PY - 2020/5
Y1 - 2020/5
N2 - Background: Essential tremor (ET), among the most common neurological diseases, is associated with cognitive dysfunction. Yet, nearly all knowledge of ET-related cognitive impairment is static and cross-sectional (e.g., prevalence), with virtually no dynamic information (i.e., course and progression, conversion rates, and clinical outcomes). Objectives: To quantify the rate of progression from mild cognitive impairment (MCI) to dementia in a cohort of elderly ET cases. Methods: 167 ET cases, enrolled in a prospective, longitudinal, clinical-pathological study, underwent an extensive neuropsychological testing battery at baseline (T1), 1.5 years (T2), and 3 years (T3). Results of these assessments informed clinical diagnoses of normal cognition (ET-NC), MCI (ET-MCI), and dementia (ET-D). Results: At baseline, 26 cases (82.7 ± 7.7 years) were diagnosed with ET-MCI and were available for follow-up at T2. At T2, three of 26 (11.5%) had converted to ET-D. At the start of T2, 23 cases (83.6 ± 7.7 years) were diagnosed with ET-MCI and were available for follow-up at T3. At T3, six of 23 (26.1%) converted to ET-D. The average annual conversion rate from ET-MCI to ET-D was 12.5%. Conclusions: The study of cognitive impairment in ET is a nascent field, with limited data. We show that the conversion rate from ET-MCI to ET-dementia was 12.5%. Available studies on historical controls have reported conversion rates of 2.6–6.3%. Data such as these systematically fill gaps in knowledge, creating a scientifically-derived knowledge base to guide physicians and patients in clinical settings.
AB - Background: Essential tremor (ET), among the most common neurological diseases, is associated with cognitive dysfunction. Yet, nearly all knowledge of ET-related cognitive impairment is static and cross-sectional (e.g., prevalence), with virtually no dynamic information (i.e., course and progression, conversion rates, and clinical outcomes). Objectives: To quantify the rate of progression from mild cognitive impairment (MCI) to dementia in a cohort of elderly ET cases. Methods: 167 ET cases, enrolled in a prospective, longitudinal, clinical-pathological study, underwent an extensive neuropsychological testing battery at baseline (T1), 1.5 years (T2), and 3 years (T3). Results of these assessments informed clinical diagnoses of normal cognition (ET-NC), MCI (ET-MCI), and dementia (ET-D). Results: At baseline, 26 cases (82.7 ± 7.7 years) were diagnosed with ET-MCI and were available for follow-up at T2. At T2, three of 26 (11.5%) had converted to ET-D. At the start of T2, 23 cases (83.6 ± 7.7 years) were diagnosed with ET-MCI and were available for follow-up at T3. At T3, six of 23 (26.1%) converted to ET-D. The average annual conversion rate from ET-MCI to ET-D was 12.5%. Conclusions: The study of cognitive impairment in ET is a nascent field, with limited data. We show that the conversion rate from ET-MCI to ET-dementia was 12.5%. Available studies on historical controls have reported conversion rates of 2.6–6.3%. Data such as these systematically fill gaps in knowledge, creating a scientifically-derived knowledge base to guide physicians and patients in clinical settings.
KW - Cerebellar diseases
KW - Cognitive aging
KW - Dementia
KW - Essential tremor
KW - Movement disorders
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U2 - 10.1016/j.parkreldis.2020.04.008
DO - 10.1016/j.parkreldis.2020.04.008
M3 - Article
C2 - 32325394
AN - SCOPUS:85083394418
SN - 1353-8020
VL - 74
SP - 38
EP - 42
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
ER -