Rapid senescence induced by overexpression of p53 in NIH3T3 cells

Jiancheng Hu, Ying Lei, Xia Hong, Zhigang Lu, Zhonghe Zhai

Research output: Contribution to journalArticlepeer-review


An NIH3T3 cell line which overexpresses temperature-sensitive p53Val135 was constructed by introduction of p53Val135 gene. It exhibited rapidly characteristic morphological and biochemical alterations related to replicative senescence when being cultured in 32 °C. We suggested that the overexpression of p53 activated probably the onset of senescence in NIH3T3 cells, which induced a rapid cellular senescence.

Original languageEnglish (US)
Pages (from-to)653-656
Number of pages4
JournalChinese Science Bulletin
Issue number8
StatePublished - 2001


  • NIH3T3
  • Overexpression
  • P53
  • P53Val135
  • Senescence

ASJC Scopus subject areas

  • General


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