Rapid development of metastatic Xp11 translocation renal cell carcinoma in a girl treated for neuroblastoma

Ryan C. Hedgepeth; Ming Zhou; Jonathan Ross

doi:10.1097/MPH.0b013e3181acd981

Rapid development of metastatic Xp11 translocation renal cell carcinoma in a girl treated for neuroblastoma

Ryan C. Hedgepeth, Ming Zhou, Jonathan Ross

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We report the case of a 5-year-old girl with metastatic renal cell carcinoma (RCC) diagnosed 19 months after treatment for neuroblastoma. Immunostaining of the secondary tumor was consistent with Xp11 translocation morphology. This is the second report of this translocation RCC presenting after neuroblastoma and the most rapid onset of RCC reported thus far. The literature regarding secondary RCC after neuroblastoma is reviewed and our case is placed within this historical context. As our understanding of the genetic changes in pediatric tumors advances, the reporting of these rare cases with specific emphasis on genetic testing provides a resource for clinicians and researchers.

Original language	English (US)
Pages (from-to)	602-604
Number of pages	3
Journal	Journal of Pediatric Hematology/Oncology
Volume	31
Issue number	8
DOIs	https://doi.org/10.1097/MPH.0b013e3181acd981
State	Published - Aug 2009

Keywords

Genetic translocation
Neuroblastoma
Renal cell carcinoma
Second primary neoplasm

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/MPH.0b013e3181acd981

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abstract = "We report the case of a 5-year-old girl with metastatic renal cell carcinoma (RCC) diagnosed 19 months after treatment for neuroblastoma. Immunostaining of the secondary tumor was consistent with Xp11 translocation morphology. This is the second report of this translocation RCC presenting after neuroblastoma and the most rapid onset of RCC reported thus far. The literature regarding secondary RCC after neuroblastoma is reviewed and our case is placed within this historical context. As our understanding of the genetic changes in pediatric tumors advances, the reporting of these rare cases with specific emphasis on genetic testing provides a resource for clinicians and researchers.",

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AB - We report the case of a 5-year-old girl with metastatic renal cell carcinoma (RCC) diagnosed 19 months after treatment for neuroblastoma. Immunostaining of the secondary tumor was consistent with Xp11 translocation morphology. This is the second report of this translocation RCC presenting after neuroblastoma and the most rapid onset of RCC reported thus far. The literature regarding secondary RCC after neuroblastoma is reviewed and our case is placed within this historical context. As our understanding of the genetic changes in pediatric tumors advances, the reporting of these rare cases with specific emphasis on genetic testing provides a resource for clinicians and researchers.

KW - Genetic translocation

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KW - Renal cell carcinoma

KW - Second primary neoplasm

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Rapid development of metastatic Xp11 translocation renal cell carcinoma in a girl treated for neuroblastoma

Abstract

Keywords

ASJC Scopus subject areas

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