Randomized Clinical Trials in Hepatocellular Carcinoma

Adam C. Yopp, William R. Jarnagin

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Hepatocellular carcinoma is among the most common solid tumors, ranking behind only lung and gastric for cancer-related deaths worldwide. Despite improved surveillance programs in many countries, most patients present with advanced-stage cancer and chronic hepatic dysfunction limiting the available treatment options. This article reviews the most pertinent randomized controlled trials with respect to surgical and adjuvant interventions that shape the current treatment algorithm for hepatocellular carcinoma.

Original languageEnglish (US)
Pages (from-to)151-162
Number of pages12
JournalSurgical Oncology Clinics of North America
Issue number1
StatePublished - Jan 2010


  • Evidence-based medicine
  • Hepatocellular carcinoma
  • Management
  • Randomized controlled trials

ASJC Scopus subject areas

  • Surgery
  • Oncology


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