Radiotherapy and immune checkpoint blockade: Potential interactions and future directions

David C. Binder; Yang Xin Fu; Ralph R. Weichselbaum

doi:10.1016/j.molmed.2015.05.007

Radiotherapy and immune checkpoint blockade: Potential interactions and future directions

David C. Binder, Yang Xin Fu, Ralph R. Weichselbaum

Research output: Contribution to journal › Short survey › peer-review

24 Scopus citations

Abstract

Combining radiation and immune checkpoint blockade provides synergistic antitumor responses in animal models and a small subset of patients. New preclinical data have provided mechanistic insight into this treatment interaction and identification of therapeutic targets to optimize this approach.

Original language	English (US)
Pages (from-to)	463-465
Number of pages	3
Journal	Trends in Molecular Medicine
Volume	21
Issue number	8
DOIs	https://doi.org/10.1016/j.molmed.2015.05.007
State	Published - Aug 1 2015

Keywords

Cancer
Immunotherapy
Radiation

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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10.1016/j.molmed.2015.05.007

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@article{ef46da802151442ebb601ec7e1dc0d3a,

title = "Radiotherapy and immune checkpoint blockade: Potential interactions and future directions",

abstract = "Combining radiation and immune checkpoint blockade provides synergistic antitumor responses in animal models and a small subset of patients. New preclinical data have provided mechanistic insight into this treatment interaction and identification of therapeutic targets to optimize this approach.",

keywords = "Cancer, Immunotherapy, Radiation",

author = "Binder, {David C.} and Fu, {Yang Xin} and Weichselbaum, {Ralph R.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = aug,

day = "1",

doi = "10.1016/j.molmed.2015.05.007",

language = "English (US)",

volume = "21",

pages = "463--465",

journal = "Trends in Molecular Medicine",

issn = "1471-4914",

publisher = "Elsevier Limited",

number = "8",

}

TY - JOUR

T1 - Radiotherapy and immune checkpoint blockade

T2 - Potential interactions and future directions

AU - Binder, David C.

AU - Fu, Yang Xin

AU - Weichselbaum, Ralph R.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Combining radiation and immune checkpoint blockade provides synergistic antitumor responses in animal models and a small subset of patients. New preclinical data have provided mechanistic insight into this treatment interaction and identification of therapeutic targets to optimize this approach.

AB - Combining radiation and immune checkpoint blockade provides synergistic antitumor responses in animal models and a small subset of patients. New preclinical data have provided mechanistic insight into this treatment interaction and identification of therapeutic targets to optimize this approach.

KW - Cancer

KW - Immunotherapy

KW - Radiation

UR - http://www.scopus.com/inward/record.url?scp=84938546841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938546841&partnerID=8YFLogxK

U2 - 10.1016/j.molmed.2015.05.007

DO - 10.1016/j.molmed.2015.05.007

M3 - Short survey

C2 - 26091823

AN - SCOPUS:84938546841

SN - 1471-4914

VL - 21

SP - 463

EP - 465

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 8

ER -

Radiotherapy and immune checkpoint blockade: Potential interactions and future directions

Abstract

Keywords

ASJC Scopus subject areas

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