Radiosurgery for high grade gliomas

J. Jagannathan, N. Pouratian, J. P. Sheehan

Research output: Contribution to journalArticlepeer-review


In the past decade, substantial advances have been made in the fields of neurological surgery and neuro-oncology. Unfortunately, the prognosis for patients with high grade gliomas and glioblastoma multi-forme (GBM) has changed very little with the majority of patients dying within months of diagnosis. Stereotactic radiosurgery is a neurosurgical modality which allows targeted treatment of residual or recurrent tumors while limiting injury to the normal brain from radiation-associated toxicity. Current reports in the literature vary as to the local tumor control rates and enhancement of life expectancy afforded high grade glioma patients with stereotactic radiosurgery. Some high grade glioma patients appear to benefit from the addition of Stereotactic radiosurgery to existing microsurgery, radiation therapy, and chemotherapy treatments.

Original languageEnglish (US)
Pages (from-to)179-185
Number of pages7
JournalRivista Medica
Issue number4
StatePublished - Dec 2007
Externally publishedYes


  • Gamma knife
  • Glioblastoma multiforme
  • High grade glioma
  • Radiobiology
  • Radiosurgery
  • Stereotaxy

ASJC Scopus subject areas

  • Surgery
  • Psychiatry and Mental health


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