TY - JOUR
T1 - Radiologic-Pathologic Correlation of Fibroepithelial Lesions
T2 - A Pictorial Review
AU - Zhang, Meng
AU - Compton, Lindsay
AU - Hwang, Helena
AU - Hayes, Jody C.
N1 - Publisher Copyright:
© Society of Breast Imaging 2022. All rights reserved.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Fibroepithelial lesions (FEL) of the breast encompass a spectrum of masses ranging from benign to malignant. Although these lesions are on the same biologic spectrum, differences in their clinical behaviors necessitate different management approaches. While imaging features are nonspecific, small size (less than 3 cm), oval shape, circumscribed margins, growth in diameter less than 20% in six months, and homogeneous echotexture on US favor fibroadenoma (FA). Conversely, larger size (3 cm or larger), rapid growth, irregular shape, noncircumscribed margins, and heterogeneous echotexture suggest possible phyllodes tumor (PT). Histopathologically, increased stromal cellularity, stromal atypia, and mitotic activity characterize PT, while FA typically lack these features. In this review, we summarize the imaging and pathology characteristics of nonmalignant FEL, including simple, juvenile, and complex FA, and benign and borderline PT and highlight the collaborative role of radiologists and pathologists in informing diagnosis and clinical management.
AB - Fibroepithelial lesions (FEL) of the breast encompass a spectrum of masses ranging from benign to malignant. Although these lesions are on the same biologic spectrum, differences in their clinical behaviors necessitate different management approaches. While imaging features are nonspecific, small size (less than 3 cm), oval shape, circumscribed margins, growth in diameter less than 20% in six months, and homogeneous echotexture on US favor fibroadenoma (FA). Conversely, larger size (3 cm or larger), rapid growth, irregular shape, noncircumscribed margins, and heterogeneous echotexture suggest possible phyllodes tumor (PT). Histopathologically, increased stromal cellularity, stromal atypia, and mitotic activity characterize PT, while FA typically lack these features. In this review, we summarize the imaging and pathology characteristics of nonmalignant FEL, including simple, juvenile, and complex FA, and benign and borderline PT and highlight the collaborative role of radiologists and pathologists in informing diagnosis and clinical management.
KW - breast mass
KW - fibroadenoma
KW - fibroepithelial lesion
KW - phyllodes tumor
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U2 - 10.1093/jbi/wbac026
DO - 10.1093/jbi/wbac026
M3 - Article
C2 - 38416944
AN - SCOPUS:85159406170
SN - 2631-6110
VL - 4
SP - 513
EP - 519
JO - Journal of Breast Imaging
JF - Journal of Breast Imaging
IS - 5
ER -