Radioisotopic assay of vitamin B12 in tissues

E. P. Frenkel, J. D. White, C. Galey, C. Croy

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The present study delineates the application of the radioisotopic competitive-inhibition assay for the measurement of vitamin B12 in tissues. The extraction of endogenous B12 from tissues was shown to be simple and complete. Proportional dilution studies suggest that tissue factors do not interfere with the assay. Although some variability exists when multiple areas of an organ are sampled, the differences between B12-deprived individuals are so wide that individual intra-organ variability is trivial. As this tissue B12 assay is similar to the widely utilized radioisotopic assays for serum B12, it is applicable for routine use.

Original languageEnglish (US)
Pages (from-to)863-869
Number of pages7
JournalAmerican journal of clinical pathology
Issue number5
StatePublished - 1976

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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