Radioactive Seed Localization: Tips and Tricks

Compared with traditional methods of pre-operative localization of non-palpable breast lesions, iodine-125 radioactive seed localization has been shown to provide better patient outcomes, including more accurate localization with smaller specimen size and fewer positive margins. Increased satisfaction of patients, surgeons, and radiologists is also demonstrated when radioactive seeds are employed for localization. This article begins with a comprehensive review of the literature regarding the evolution of this increasingly utilized technique and then emphasizes the key points to develop and maintain a successful radioactive seed localization program. Insertion of radioactive seeds for breast localization purposes requires special considerations before, during, and after the procedure, which will be highlighted in addition to practical advice for accurate seed placement.