r84, a novel therapeutic antibody against mouse and human vegf with potent anti-tumor activity and limited toxicity induction

Agriculture & Biology

• vascular endothelial growth factors 100%
• vascular endothelial growth factor receptors 56%
• therapeutics 56%
• neoplasms 55%
• toxicity 49%
• antibodies 48%
• mice 42%
• receptors 22%
• endothelial cells 13%
• vascular endothelial growth factor receptor-2 11%
• assays 10%
• neoplasm progression 9%
• angiogenesis 8%
• blood chemistry 7%
• mitogens 7%
• carcinogenesis 7%
• histology 6%
• blood pressure 6%
• cells 6%
• cell viability 6%
• tyrosine 6%
• chemistry 5%
• monoclonal antibodies 5%
• phosphotransferases (kinases) 5%
• permeability 5%
• urine 5%
• enzyme-linked immunosorbent assay 5%
• dosage 3%
• tissues 2%

Medicine & Life Sciences

• Vascular Endothelial Growth Factor A 62%
• Vascular Endothelial Growth Factor Receptor 48%
• Antibodies 40%
• Neoplasms 23%
• Vascular Endothelial Growth Factor Receptor-2 20%
• Tumor Microenvironment 16%
• Physiologic Neovascularization 12%
• Neuropilin-1 12%
• Endothelial Cells 12%
• Therapeutics 11%
• human VEGFA protein 11%
• Pathologic Neovascularization 11%
• Chemotactic Factors 9%
• Cell Surface Receptors 8%
• Receptor Protein-Tyrosine Kinases 8%
• Mitogens 8%
• Permeability 6%
• Histology 6%
• Carcinogenesis 6%
• Cell Survival 6%
• Monoclonal Antibodies 5%
• Urine 5%
• Enzyme-Linked Immunosorbent Assay 5%
• Blood Pressure 5%
• Safety 4%

Chemical Compounds

• Mitogen 7%
• Block Like Crystal 7%
• Chemotactic 6%
• Blood Pressure 6%
• Cell Viability 5%
• Tyrosine 4%
• Safety 4%
• Permeability 4%
• Dose 3%
• Chemistry 3%
• Surface 1%