TY - GEN
T1 - Quantitative Iodine-124 imaging on animal PET
AU - Yao, Rutao
AU - Balakrishnan, Swaminathan
AU - Ambwani, Sonal
AU - Rathod, Vinay
AU - Shao, Yiping
PY - 2005
Y1 - 2005
N2 - With a half-live of 4.2 days, Iodine-124 (124I) is suitable for studying antibodies and drug analogues in animals that have a biological half-live in days. The special challenges with 124I imaging on animal PET are: 1) the high fraction of high-energy, non-annihilation gamma-rays that introduce true coincidences which elevate the image background activity, and 2) the significant degradation of spatial resolution due to the high positron energies. By simulations and experiments on an animal PET scanner, we characterized these two unique degradation factors and evaluated the corresponding correction methods. The preliminary results of applying non-annihilation true coincidence correction and using 124I specific point spread function in the system matrix of reconstruction algorithm showed improved contrast and resolution recovery. These findings indicate that higher-resolution, quantitative 124I applications can be achieved.
AB - With a half-live of 4.2 days, Iodine-124 (124I) is suitable for studying antibodies and drug analogues in animals that have a biological half-live in days. The special challenges with 124I imaging on animal PET are: 1) the high fraction of high-energy, non-annihilation gamma-rays that introduce true coincidences which elevate the image background activity, and 2) the significant degradation of spatial resolution due to the high positron energies. By simulations and experiments on an animal PET scanner, we characterized these two unique degradation factors and evaluated the corresponding correction methods. The preliminary results of applying non-annihilation true coincidence correction and using 124I specific point spread function in the system matrix of reconstruction algorithm showed improved contrast and resolution recovery. These findings indicate that higher-resolution, quantitative 124I applications can be achieved.
UR - http://www.scopus.com/inward/record.url?scp=33846579041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846579041&partnerID=8YFLogxK
U2 - 10.1109/NSSMIC.2005.1596636
DO - 10.1109/NSSMIC.2005.1596636
M3 - Conference contribution
AN - SCOPUS:33846579041
SN - 0780392213
SN - 9780780392212
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 1649
EP - 1652
BT - 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
T2 - Nuclear Science Symposium Conference Record, 2005 IEEE
Y2 - 23 October 2005 through 29 October 2005
ER -