Quantification of valve regurgitation by radionuclide angiography before and after valve replacement surgery

Joann Urquhart, Randolph E. Patterson, Milton Packer, Stanley J. Goldsmith, Steven F. Horowitz, Robert Litwak, Richard Gorlin

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Radionuclide gated cardiac blood pool imaging was used to quantify the severity of valve regurgitation in 20 patients, by calculating the ratio of left ventricular to right ventricular stroke counts (end-diastolic minus end-systolic counts in right and left ventricular regions of interest). This ratio (the stroke index ratio) was substantially higher in patients with aortic and mitral regurgitation (3.91 ± 1.45) than in a control group of 10 patients without regurgitation (1.32 ± 0.15), p < 3.001. The stroke index ratio correlated closely (r = 0.947) with measurements of regurgitant fraction derived from simultaneous determinations of total and forward stroke volumes during cardiac catheterization. After aortic and mitral valve replacement in 18 patients, the stroke index ratio decreased from 4.03 ± 1.46 to 1.38 ± 0.23 (p < 0.001), a value not significantly different from that observed in patients without regurgitation. All three patients with residual postoperative regurgitation had a stroke index ratio greater than 2 standard deviations above the mean values for the control group (>1.62), whereas the remaining 15 patients, who had no evidence of regurgitation, had values within the normal range. Therefore, radionuclide gated blood pool scanning provides a noninvasive method of quantifying valve regurgitation and assessing the results of medical or surgical interventions.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalThe American journal of cardiology
Issue number2
StatePublished - Feb 1981

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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