QT Interval Prolongation in the Pediatric Oncologic Population on Methadone

Jenna A. Piccininni; James S. Killinger; Hoda T. Hammad; Linda M. Gerber; Jeffrey D. Dayton

doi:10.1097/MPH.0000000000001444

QT Interval Prolongation in the Pediatric Oncologic Population on Methadone

Jenna A. Piccininni, James S. Killinger, Hoda T. Hammad, Linda M. Gerber, Jeffrey D. Dayton

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Studies have been conducted on adults prescribed with methadone to determine the necessary frequency of QTc monitoring but no consensus has been reached and no similar research has been conducted in the pediatric population. The objective of this retrospective study was to determine the occurrence rate of QTc interval prolongation associated with methadone use in a pediatric oncologic population. In total, 18% of patients developed QTc interval prolongation. These patients had longer baseline QTc intervals and were on more QTc interval-prolonging medications. Our data suggest that these variables may be able to risk stratify patients who require more frequent monitoring.

Original language	English (US)
Pages (from-to)	E121-E124
Journal	Journal of Pediatric Hematology/Oncology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1097/MPH.0000000000001444
State	Published - Mar 1 2020
Externally published	Yes

Keywords

QTc prolongation
pediatric oncology
torsades des pointes
ventricular arrhythmia

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/MPH.0000000000001444

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abstract = "Studies have been conducted on adults prescribed with methadone to determine the necessary frequency of QTc monitoring but no consensus has been reached and no similar research has been conducted in the pediatric population. The objective of this retrospective study was to determine the occurrence rate of QTc interval prolongation associated with methadone use in a pediatric oncologic population. In total, 18% of patients developed QTc interval prolongation. These patients had longer baseline QTc intervals and were on more QTc interval-prolonging medications. Our data suggest that these variables may be able to risk stratify patients who require more frequent monitoring.",

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AU - Killinger, James S.

AU - Hammad, Hoda T.

AU - Gerber, Linda M.

AU - Dayton, Jeffrey D.

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AB - Studies have been conducted on adults prescribed with methadone to determine the necessary frequency of QTc monitoring but no consensus has been reached and no similar research has been conducted in the pediatric population. The objective of this retrospective study was to determine the occurrence rate of QTc interval prolongation associated with methadone use in a pediatric oncologic population. In total, 18% of patients developed QTc interval prolongation. These patients had longer baseline QTc intervals and were on more QTc interval-prolonging medications. Our data suggest that these variables may be able to risk stratify patients who require more frequent monitoring.

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KW - torsades des pointes

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QT Interval Prolongation in the Pediatric Oncologic Population on Methadone

Abstract

Keywords

ASJC Scopus subject areas

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